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Identity of the photoproduct that causes lacI mutations in UV-irradiated Escherichia coli. |
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| Authors: | C W Lawrence R B Christensen and J R Christensen |
| Abstract: | Estimates of the capacity of photoreactivation to act specifically on premutational lesions were obtained by conjugational transfer of an F' lac plasmid from a UV-irradiated, photoreactivated donor to a delta (pro-lac) recipient that had been UV irradiated and allowed to induce SOS functions for 30 min. This treatment reduced the frequency of induced lacI mutations by 70 to 80%, indicating that cyclobutane dimers cause most mutations in this system. |
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