Pyranochromones from Dictyoloma vandellianum A. Juss and Their Cytotoxic Evaluation |
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| Authors: | Iura M Alves Lucas S Abreu Cinara O S Costa Mireille Le Hyaric Maria Lenise S Guedes Milena B P Soares Daniel P Bezerra Eudes S Velozo |
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| Affiliation: | 1. Institute of Chemistry, Federal University of Bahia, Salvador, BA, Brazil;2. College of Pharmacy, Federal University of Bahia, Salvador, BA, Brazil;3. Gon?alo Moniz Institute, Oswaldo Cruz Foundation, Salvador, BA, Brazil;4. Department of Chemistry, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil;5. Institute of Biology, Federal University of Bahia, Salvador, BA, Brazil |
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| Abstract: | One new chromone 3,3‐dimethylallylspatheliachromene methyl ether ( 1 ), as well as five known chromones, 6‐(3‐methylbut‐2‐enyl) allopteroxylin methyl ether ( 2 ), 6‐(3‐methylbut‐2‐enyl) allopteroxylin ( 3 ), 3,3‐dimethylallylspatheliachromene ( 4 ), 5‐O‐methylcneorumchromone K ( 5 ) and spatheliabischromene ( 6 ), two alkaloids, 8‐methoxy‐N‐methylflindersine ( 7 ) and 8‐methoxyflindersine ( 8 ), and two limonoids, limonin diosphenol ( 9 ) and rutaevin ( 10 ), were isolated from Dictyoloma vandellianum A. Juss (Rutaceae). Cytotoxic activities towards tumor cell lines B16‐F10, HepG2, K562 and HL60 and non‐tumor cells PBMC were evaluated for compounds 1 – 6 . Compound 1 was the most active showing IC50 values ranging from 6.26 to 14.82 μg/ml in B16‐F10 and K562 cell lines, respectively, and presented IC50 value of 11.65 μg/ml in PBMC cell line. |
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| Keywords: | Chromones Limonoids Alkaloids Cytotoxic activities
Dictyoloma
Rutaceae |
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