New Furanone Derivatives and Alkaloids from the Co‐Culture of Marine‐Derived Fungi Aspergillus sclerotiorum and Penicillium citrinum |
| |
| Authors: | Jie Bao Jie Wang Xiao‐Yong Zhang Xu‐Hua Nong Shu‐Hua Qi |
| |
| Affiliation: | Key Laboratory of Tropical Marine Bio‐resources and Ecology, Guangdong Key Laboratory of Marine Material Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China |
| |
| Abstract: | Six new compounds including two furanone derivatives sclerotiorumins A and B ( 1 and 2 ), one novel oxadiazin derivative sclerotiorumin C ( 3 ), one pyrrole derivative 1‐(4‐benzyl‐1H‐pyrrol‐3‐yl)ethanone ( 4 ), and two complexes of neoaspergillic acid aluminiumneohydroxyaspergillin ( 5 ) and ferrineohydroxyaspergillin ( 6 ) were isolated from the co‐culture of marine‐derived fungi Aspergillus sclerotiorum and Penicillium citrinum. Compound 3 was the first natural 1,2,4‐oxadiazin‐6‐one. Compound 5 showed significant and selective cytotoxicity against human histiocytic lymphoma U937 cell line (IC50 = 4.2 μm ) and strong toxicity towards brine shrimp (LC50 = 6.1 μm ), and oppositely increased the growth and biofilm formation of Staphylococcus aureus. |
| |
| Keywords: |
Aspergillus sclerotiorum
Furanone derivatives Complexes of neoaspergillic acid 1 2 4‐Oxadiazin‐6‐one Cytotoxic activities |
|
|
