Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells |
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| Authors: | Nguyen Xuan Nhiem Nguyen Trung Tuong Pham Thanh Ky Lalita Subedi Seon Ju Park Tran Minh Ngoc Pham Hai Yen Bui Huu Tai Tran Hong Quang Phan Van Kiem Sun Yeou Kim Seung Hyun Kim |
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| Affiliation: | 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Caugiay, Hanoi, Vietnam;2. National Institute of Medicinal Materials, Hoankiem, Hanoi, Vietnam;3. Hanoi University of Pharmacy, Hoankiem, Hanoi, Vietnam;4. College of Pharmacy, Gachon University, Incheon, Korea;5. College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, Korea |
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| Abstract: | Phaeanthus vietnamensis Bân is a well‐known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8′R)‐9,9′‐epoxy‐3,5,3′,5′‐tetramethoxylignan‐4,4′,7‐triol ( 1 ), 8α‐hydroxyoplop‐11(12)‐en‐14‐one ( 5 ), and (1R,2S,4S)‐4‐acetyl‐2‐(E)‐(cinnamoyloxy)]‐1‐methylcyclohexan‐1‐ol ( 12 ) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS‐stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS‐stimulated NO production in BV2 cells with the IC50 values of 15.7 ± 1.2 μm . Compounds 2 , 7 , and 8 significantly inhibited inflammatory NO production with IC50 values ranging from 22.6 to 25.3 μm . |
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| Keywords: |
Phaeanthus vietnamensis
Annonaceae Sesquiterpene Lignan Aromandendrane Anti‐inflammatory activities |
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