Plk1 puts a (Has)pin on the mitotic histone code |
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| Authors: | Tatiana Moutinho‐Santos Helder Maiato |
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| Affiliation: | 1. Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal;2. Department of Experimental Biology, Faculdade de Medicina, Universidade do Porto, Porto, Portugal |
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| Abstract: | Haspin is an atypical mitotic kinase that phosphorylates histone H3 on threonine 3 (H3T3), which is required to target Aurora B to centromeres. However, how Haspin is activated upon mitotic entry remained unknown. Two independent studies, published in Molecular Cell and in this issue of EMBO reports by Ghenoiu et al [1] and Zhou et al [2], respectively, now show that Plk1 is responsible for Haspin activation as a H3T3 kinase. These results shed light on the spatiotemporal regulation of Aurora B to ensure mitotic fidelity. |
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