|
|||||
|
|
Intravascular magnetomotive optical coherence tomography of targeted early‐stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas |
|
| Authors: | Jongsik Kim Adeel Ahmad Joanne Li Marina Marjanovic Eric J Chaney Kenneth S Suslick Stephen A Boppart |
| Affiliation: | 1. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana‐Champaign, Urbana, IL, USA;2. Department of Electrical and Computer Engineering, University of Illinois at Urbana‐Champaign, Champaign, IL, USA;3. Department of Bioengineering, University of Illinois at Urbana‐Champaign, Urbana, IL, USA;4. Department of Chemistry, University of Illinois at Urbana‐Champaign, Urbana, IL, USA;5. +01 217 333 8598+01 217 333 5833;6. Department of Internal Medicine, University of Illinois at Urbana‐Champaign, Urbana, IL, USA |
| Abstract: | We report the development of an intravascular magnetomotive optical coherence tomography (IV‐MM‐OCT) system used with targeted protein microspheres to detect early‐stage atherosclerotic fatty streaks/plaques. Magnetic microspheres (MSs) were injected in vivo in rabbits, and after 30 minutes of in vivo circulation, excised ex vivo rabbit aorta samples specimens were then imaged ex vivo with our prototype IV‐MM‐OCT system. The alternating magnetic field gradient was provided by a unique pair of external custom‐built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a statistically significant MM‐OCT signal from the aorta samples specimens injected with targeted MSs.  Representative magnetomotive signal (green) using targeted and non‐targeted magnetomotive microspheres in atherosclerotic diseased rabbit aortas. |
| Keywords: | optical coherence tomography catheter magnetomotive protein microspheres fatty streaks atherosclerosis α vβ 3 integrin |
