Population structure of a vector of human diseases: Aedes aegypti in its ancestral range,Africa |
| |
| Authors: | Panayiota Kotsakiozi Benjamin R Evans Andrea Gloria‐Soria Basile Kamgang Martin Mayanja Julius Lutwama Gilbert Le Goff Diego Ayala Christophe Paupy Athanase Badolo Joao Pinto Carla A Sousa Arlete D Troco Jeffrey R Powell |
| |
| Affiliation: | 1. Yale University, New Haven, Connecticut;2. Centre for Research in Infectious Diseases, Yaoundé, Cameroon;3. Uganda Virus Research Institute, Entebbe, Uganda;4. MIVEGEC Laboratory (UMR IRD 224‐5290 CNRS‐UM), Institut de Recherche pour le développement (IRD), Montpellier, France;5. IRD La Réunion‐GIP CYROI, La Réunion, France;6. Centre International de Recherches Médicales de Franceville (CIRMF), Franceville, Gabon;7. Laboratoire d'Entomologie Fondamentale et Appliquée, Université Ouaga 1 Pr Joseph KI‐ZERBO, Ouagadougou 03, Burkina Faso;8. Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisbon, Portugal;9. Programa Nacional de Controle da Malária, Direc??o Nacional de Saúde Pública, Ministério da Saúde, Luanda, Angola |
| |
| Abstract: | Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. There is little doubt that the ancestral home of the species is Africa. This mosquito invaded the New World 400‐500 years ago and later, Asia. However, little is known about the genetic structure and history of Ae. aegypti across Africa, as well as the possible origin(s) of the New World invasion. Here, we use ~17,000 genome‐wide single nucleotide polymorphisms (SNPs) to characterize a heretofore undocumented complex picture of this mosquito across its ancestral range in Africa. We find signatures of human‐assisted migrations, connectivity across long distances in sylvan populations, and of local admixture between domestic and sylvan populations. Finally, through a phylogenetic analysis combined with the genetic structure analyses, we suggest West Africa and especially Angola as the source of the New World's invasion, a scenario that fits well with the historic record of 16th‐century slave trade between Africa and Americas. |
| |
| Keywords: |
Aedes aegypti
Africa genetics migration population structure SNP‐chip |
|
|
