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Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues. |
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| Authors: | J Srinivasappa J Saegusa B S Prabhakar M K Gentry M J Buchmeier T J Wiktor H Koprowski M B Oldstone A L Notkins |
| Abstract: | More than 600 monoclonal antiviral antibodies made against 11 different viruses were screened against 14 different organs from normal uninfected mice. Of these antiviral antibodies, 21, or approximately 3.5%, reacted with specific cells in these organs. Several of these antibodies were of the multiple-organ-reactive type and recognized antigens in more than one organ. It was concluded that the reactivity of monoclonal antiviral antibodies with normal tissues is a common phenomenon. |
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