| 大豆异黄酮对游泳小鼠能量代谢的影响 |
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| 引用本文： | 邓炳楠,孙景然,金宏,聂鸿靖,段瑞峰,刘列,高志贤,陈照立.大豆异黄酮对游泳小鼠能量代谢的影响[J].中国应用生理学杂志,2018,34(1):39-42. |
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| 作者姓名： | 邓炳楠 孙景然 金宏 聂鸿靖 段瑞峰 刘列 高志贤 陈照立 |
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| 作者单位： | 军事科学院 军事医学研究院 环境医学与作业医学研究所, 天津 300050 |
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| 基金项目： | BWS (16J009,8147182) |
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| 摘 要： | 目的：探讨大豆异黄酮（SI）对游泳小鼠能量代谢的影响。方法：建立小鼠运动疲劳模型，选用雄性昆明小鼠30只，根据体质量随机分为3组（n=10）：正常组、游泳模型组、游泳+SI干预组（SI组）。正常组及模型组小鼠以AIN-93M合成饲料饲养，SI组在AIN-93M合成饲料中添加相应剂量的SI （4 g/kg）。饲养2周后，模型组和SI组小鼠负重2%游泳1 h后处死，测定其血乳酸（Lac）含量及乳酸脱氢酶（LDH）、琥珀酸脱氢酶（SDH）、肌酸激酶（CK）、ATP酶的活性。结果：与正常组相比，模型组和SI组血清中Lac含量明显增加（P<0.05），模型组肌肉和SI组血中LDH活性显著升高（P<0.05），模型组血清、肝脏和肌肉中SDH和CK活性明显升高，SI组血清和肌肉中SDH和CK活性显著升高（P<0.05）；与模型组相比，SI组小鼠游泳后，血清Lac含量明显下降（P<0.05），LDH、SDH、CK酶活性较模型组都有明显升高（P<0.05）。结论：大豆异黄酮对游泳小鼠能量代谢具有一定的调节作用。
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| 关 键 词： | 大豆异黄酮 能量代谢 游泳小鼠 |
| 收稿时间： | 2016-10-18 |
Effects of soybean isoflavones on the energy metabolism of swimming mice |
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| DENG Bing-nan,SUN Jing-ran,JIN Hong,NIE Hong-jing,DUAN Rui-feng,LIU Lie,GAO Zhi-xian,CHEN Zhao-li.Effects of soybean isoflavones on the energy metabolism of swimming mice[J].Chinese Journal of Applied Physiology,2018,34(1):39-42. |
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| Authors: | DENG Bing-nan SUN Jing-ran JIN Hong NIE Hong-jing DUAN Rui-feng LIU Lie GAO Zhi-xian CHEN Zhao-li |
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| Affiliation: | Institute of Environmental and Operational Medicine, Tianjin 300050, China |
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| Abstract: | Objective: To establish an animal model for loaded swimming, so as to investigate the energy metabolism effects of soybean isoflavones (SI) on swimming mice.Methods: Thirty male Kunming mice were randomly divided into three groups:normal control, swimming group, and swimming+SI group. The normal control group mice were fed a basic AIN-93M diet, the SI groups were supplied with soybean isoflavones(4 g/kg).Two weeks later, the mice were forced to swim for an hour,and then all the mice were killed, the samples of blood, liver and muscles of hind were collected.The serum contents of lactic acid(Lac), the activities of lactic dehydrogenase (LDH), succinate dehydrogenase (SDH), creatine kinase (CK) and ATPase were measured.Results: Compared with normal control,the serum content of Lac was significantly improved in the group of the swimming control and SI(P<0.05),the activity of LDH in the serum was obviously improved in the group of the swimming control and SI, and the activity of CK and SDH were both significantly improved in the group of the swimming control and SI except the activity of SDH in the liver of the group SI; compared with the swimming control,the serum contents of Lac,the activities of LDH, ATPase, SDH, CK were obviously improved(P<0.05).Conclusion: Soybean isoflavones can improve the energy metabolism,antioxidant capacity of the swimming mice. |
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| Keywords: | soybean isoflavones energy metabolism swimming mice |
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