Immunochemical studies on the capsular polysaccharides of pneumococcal type IX |
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| Authors: | John D. Higginbotham Amalendu Das Michael Heidelberger |
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| Affiliation: | Department of Pathology, New York University School of Medicine, New York, N.Y. 10016, U.S.A. |
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| Abstract: | ![]()
1. In addition to the previously identified components, d-glucose, N-acetyl-d-glucosamine and d-glucuronic acid, the immunologically specific capsular polysaccharide of pneumococcal type IX (polysaccharide S IX) is now found to contain mannosamine and galactosamine, probably as their N-acetyl derivatives. 2. Partial hydrolysis yields a complex mixture of oligosaccharides, several of which have been separated. 3. One of these is alpha-d-glucuronopyranosyl-(1-->3)-d-glucose. It is an inhibitor of the precipitation of antipneumococcal type IX serum by polysaccharide S IX. 4. Two others, d-glucuronopyranosyl-(1-->3)-d-glucosamine and d-glucuronopyranosyl-(1-->3)-d-galactosamine have been identified and a trisaccharide and pentasaccharide partially characterized. |
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