Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection. |
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| Authors: | H Shida T Tochikura T Sato T Konno K Hirayoshi M Seki Y Ito M Hatanaka Y Hinuma M Sugimoto |
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| Affiliation: | Institute for Virus Research, Kyoto University, Japan. |
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| Abstract: | The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV-I in rabbits and had a protective effect against HTLV-I infection. |
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