Specificity of the effect of dietary cholesterol on rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity (Short Communication) |
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| Authors: | Keith W Gregory and Roger Booth |
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| Affiliation: | Department of Biochemistry, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, U.K. |
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| Abstract: | Dietary cholesterol lowers the activity of rat liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase without affecting various other liver microsomal enzymes. This is consistent with a specific regulatory mechanism and distinguishes the action of cholesterol on 3-hydroxy-3-methylglutaryl-CoA reductase from that of at least one other stimulus known to affect this enzyme. |
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