Biological Characterization of Rev Variation in Equine Infectious Anemia Virus |
| |
| Authors: | Michael Belshan Matthew E Harris Anne E Shoemaker Thomas J Hope and Susan Carpenter |
| |
| Affiliation: | Department of Microbiology, Immunology, and Preventive Medicine, Iowa State University, Ames, Iowa 50011,1. and Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 920372. |
| |
| Abstract: | Sequence analysis identified significant variation in the second exon of equine infectious anemia virus (EIAV) rev. Functional analysis indicated that limited amino acid variation in Rev significantly altered the export activity of the protein but did not affect Rev-dependent alternative splicing. EIAV Rev can mediate export through two independent cis-acting Rev-responsive elements (RREs), and differences among Rev variants were more pronounced when both RREs were present. Variation in Rev may be an important mechanism for regulation of virus replication in vivo and may contribute to changes in clinical disease. |
| |
| Keywords: | |
|
|
