Long-term productive human immunodeficiency virus infection of CD1a-sorted myeloid dendritic cells |
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| Authors: | Popov Sergei Chenine Agnès-Laurence Gruber Andreas Li Pei-Lin Ruprecht Ruth M |
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| Affiliation: | Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02115-6084, USA. |
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| Abstract: | Myeloid, CD1a-sorted dendritic cells (MDC) productively replicated human immunodeficiency virus strains encoding envelope genes of either primary X4R5 or R5 strains for up to 45 days. Cell-free supernatant collected from long-term infected MDC, which had been exposed to an X4R5 virus 45 days earlier, was still infectious when placed over activated T cells. These data imply that DC can act as a persistent reservoir of infectious virus. |
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