Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10 |
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| Authors: | Verhoeven Kristien De Jonghe Peter Van de Putte Tom Nelis Eva Zwijsen An Verpoorten Nathalie De Vriendt Els Jacobs An Van Gerwen Veerle Francis Annick Ceuterick Chantal Huylebroeck Danny Timmerman Vincent |
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| Affiliation: | Molecular Genetics Department, Flanders Interuniversity Institute for Biotechnology, Antwerp, Belgium. |
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| Abstract: | Slowed nerve-conduction velocities (NCVs) are a biological endophenotype in the majority of the hereditary motor and sensory neuropathies (HMSN). Here, we identified a family with autosomal dominant segregation of slowed NCVs without the clinical phenotype of HMSN. Peripheral-nerve biopsy showed predominantly thinly myelinated axons. We identified a locus at 8p23 and a Thr109Ile mutation in ARHGEF10, encoding a guanine-nucleotide exchange factor (GEF) for the Rho family of GTPase proteins (RhoGTPases). Rho GEFs are implicated in neural morphogenesis and connectivity and regulate the activity of small RhoGTPases by catalyzing the exchange of bound GDP by GTP. Expression analysis of ARHGEF10, by use of its mouse orthologue Gef10, showed that it is highly expressed in the peripheral nervous system. Our data support a role for ARHGEF10 in developmental myelination of peripheral nerves. |
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