The BpsIR quorum-sensing system of Burkholderia pseudomallei |
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Authors: | Song Yan Xie Chao Ong Yong-Mei Gan Yunn-Hwen Chua Kim-Lee |
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Affiliation: | Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Dr., Singapore 117597, Singapore. |
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Abstract: | BpsIR, a LuxIR quorum-sensing homolog, is required for optimal expression of virulence and secretion of exoproducts in Burkholderia pseudomallei. Cell density-dependent expression of bpsI and bpsR, the positive regulation of bpsIR expression by BpsR, and the synthesis of N-octanoyl-homoserine lactone (C8HSL) by BpsI are described in this report. |
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