Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype |
| |
| Authors: | Scripture-Adams Deirdre D Brooks David G Korin Yael D Zack Jerome A |
| |
| Affiliation: | Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA. |
| |
| Abstract: | Latent human immunodeficiency virus type 1 (HIV-1) persists even in patients treated with antiretroviral therapy. New treatment strategies are therefore needed to eradicate this latent viral reservoir without reducing immune cell function. We characterize the interleukin-7 (IL-7)-induced stimulation of primary human T cells and thymocytes and demonstrate, using the SCID-hu model, that IL-7 induces substantial expression of latent HIV while having minimal effects on the cell phenotype. Thus, IL-7 is a viable candidate to activate expression of latent HIV and may facilitate immune clearance of latently infected cells. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
