Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut |
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| Authors: | Wilson David P Mattapallil Joseph J Lay Matthew D H Zhang Lei Roederer Mario Davenport Miles P |
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| Affiliation: | Department of Haematology, Prince of Wales Hospital, University of New South Wales, Kensington, New South Wales, Australia. |
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| Abstract: | CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo. |
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