Sequences adjacent to oriP improve the persistence of Epstein-Barr virus-based episomes in B cells |
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| Authors: | White R E Wade-Martins R James M R |
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| Affiliation: | Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom. |
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| Abstract: | Epstein-Barr virus (EBV) oriP and the EBV nuclear antigen 1 (EBNA-1) protein allow persistence of EBV-based episomes. A nuclear matrix attachment region (MAR) spans oriP and the adjacent region of the EBV genome containing the EBV-expressed RNAs. Here, we show that episomes with the MAR are retained significantly more efficiently in EBV-positive B cells than episomes containing oriP alone. |
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