Trace analysis of N‐acetyl‐L‐cysteine using luminol–H2O2 chemiluminescence system catalyzed by silver nanoparticles |
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| Authors: | Abdolraouf Samadi‐Maybodi Reza Akhoondi |
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| Affiliation: | Analytical Division, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran |
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| Abstract: | N‐Acetyl‐L‐cysteine (NAC) can inhibit the luminol–H2O2, reaction, which is catalyzed by silver nanoparticles. Based on this phenomenon a new method was developed for NAC determination. Under optimum conditions, a linear relationship between chemiluminescence intensity and NAC concentration was found in the range 0.034–0.98 µg/mL. The detection limit was 0.010 µg/mL (S/N =3), and the relative standard deviation (RSD) was <5% for 0.480 µg/mL NAC (n =5). This simple, sensitive and inexpensive method has been applied to measure the concentration of NAC in pharmaceutical tablets. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | N‐acetyl‐L‐cysteine silver nanoparticles luminol chemiluminescence pharmaceutical tablet |
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