Effect of Viral Double-Stranded RNA on Protein Synthesis in Intact Cells |
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| Authors: | B. Cordell-Stewart and Milton W. Taylor |
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| Affiliation: | 1Department of Microbiology, Indiana University, Bloomington, Indiana 47401 |
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| Abstract: | The addition of purified, noninfectious, double-stranded RNA of bovine enterovirus, a picornavirus, to intact cells in culture results in a rapid cessation of cellular polypeptide synthesis. This inhibition is specific for host cell protein synthesis since the translation of picornavirus-specific proteins is not affected by the double-stranded viral RNA. |
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