Ubiquitination of the human immunodeficiency virus type 1 env glycoprotein |
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| Authors: | Bültmann A Eberle J Haas J |
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| Affiliation: | Max-von-Pettenkofer Institut, Genzentrum, LMU München, 81377 Munich, Germany. |
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| Abstract: | Expression of the human immunodeficiency virus type 1 (HIV-1) Env glycoprotein is stringently regulated in infected cells. The majority of the glycoprotein does not reach the cell surface but rather is retained in the endoplasmic reticulum or a cis-Golgi compartment and subsequently degraded. We here report that Env of various HIV-1 isolates is ubiquitinated at the extracellular domain of gp41 and that Env expression could be increased by lactacystin, a specific proteasome inhibitor, suggesting that the ubiquitin/proteasome system is involved in control of expression and degradation. |
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