Inhibition of gammaherpesvirus replication by RNA interference |
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| Authors: | Jia Qingmei Sun Ren |
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| Affiliation: | Department of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California 90095, USA. |
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| Abstract: | RNA interference (RNAi) is a conserved mechanism in which double-stranded, small interfering RNAs (siRNAs) trigger a sequence-specific gene-silencing process. Here we describe the inhibition of murine herpesvirus 68 replication by siRNAs targeted to sequences encoding Rta, an immediate-early protein known as an initiator of the lytic viral gene expression program, and open reading frame 45 (ORF 45), a conserved viral protein. Our results suggest that RNAi can block gammaherpesvirus replication and ORF 45 is required for efficient viral production. |
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