概述了近10年来利用结构生物学和蛋白质工程技术在纤维素酶分子结构和功能方面研究的进展,包括:酶分子结构域的拆分、催化域和纤维素结合结构域的结构和功能的研究,纤维素酶的分子折叠.并展望了该领域的研究前景.
The recent advance in structure-function studies of cellulases by structural biology and protein engineering is reviewed.The seperation of structural domains and the structure-function studies of catalytic domains and cellulose-binding domains are included.The research prospects of cellulases are forecasted.According to the sequence similarity of amino acid, cellulase and hemicellulase can be divided in to nine families, and in five families there are some enzymes that three dimension structure have been resolved.Here, three dimension structure of some cellulase and xylanase were compared, and the relationship between its molecular folding and catalytic mechanism were also analyzed.
阎伯旭,齐飞,张颖舒,高培基.纤维素酶分子结构和功能研究进展[J].生物化学与生物物理进展,1999,26(3):233-237
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