Abstract: Quorum sensing (QS) refers to the behavior of microorganisms to control gene expression through detection the concentration of certain signal molecules，which is correlated with cell density． In many class Ⅱ bacteriocin-producing lactic acid bacteria (LAB)，bacteriocin production is regulated by peptide pheromones via a QS mechanism． We reviewed，QS regulated class Ⅱ bacteriocin production in LAB and its regulation mechanism，components of the QS system，as well as the application of QS mechanism． The study of QS mechanism of class Ⅱ bacteriocin-producing LAB may provide a new platform for revealing the mechanism of fermentation control and regulating fermentation process． It also offers an alternative to the exploitation of food grade gene expression system．