稀有糖是在自然界中存在但含量极少的一类单糖及衍生物，其在膳食、保健、医药等领域中发挥着重要的功能。本文综述了一种稀有糖的生物转化生产策略----Izumoring方法，即利用D-塔格糖3-差向异构酶、醛糖异构酶和多元醇脱氢酶等进行所有单糖及糖醇之间的相互转化；利用该原则，分别构建了己糖类、戊糖类和丁糖类的Izumoring转化策略，并可获得所有稀有糖的酶反应和生物转化生产途径。同时，展望了稀有糖生物转化生产的研究趋势。
Rare sugars were defined as monosaccharides and their derivatives that rarely exist in nature. They played an important role in food, health, medicine and etc.. A strategy for bioproduction of rare sugars, namely Izumoring, was reviewed in this paper. By the Izumoring method, all monosaccharides and polyols could be linked using enzymatic reaction with D-tagatose 3-epimerase, aldose isomerases and polyol dehydrogenases. According to this strategy, the Izumoring for hexoses, pentoses and tetroses were designed respectively, and the bioproduction routes of various rare sugars, using microbial and enzymatic reactions, could be obtained.
沐万孟,张涛,江波,张华. 稀有糖的生物转化生产策略：Izumoring方法[J]. 中国生物工程杂志, 2007, 27(7): 129-136.
. A strategy for bioproduction of rare sugars: Izumoring. China Biotechnology, 2007, 27(7): 129-136.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2007/V27/I7/129
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