目的 评价羟基磷灰石(hydroxyapatite, HAP)涂层的AZ31B镁合金（HAP/AZ31B）作为植入材料的生物安全性。方法 采用恒电压阴极电沉积法制备表面HAP涂层的HAP/AZ31B材料；判定生物材料的致突变及毒性作用；检测材料表面的腐蚀状况并进行能谱分析。结果 HAP/AZ31B材料无致突变作用，对动物组织未产生严重的炎症反应；经HAP涂层后的AZ31B材料腐蚀较慢，微核出现率为4.4‰，溶血率为0.25%。结论HAP/AZ31B表现出较好的生物安全性和相容性，有可能成为新型可降解骨支架材料。
Objective: to evaluate biological safety of HAP/AZ31B as implanted material. Methods: HAP/AZ31B biomaterial was prepared by cathodic electrodeposition with constant voltage technique, and then biocompatibility was assessed. The corrosion of surface was detected by spectrum analysis. Results: HAP/AZ31B had no mutagenesis and toxic effect. Serious inflammatory reaction was not induced. The corrosion velocity of HAP/AZ31B was slower. The micronucleus frequency and hemolysis of HAP/AZ31B leaching liquor was 4.4‰ and 0.25%, respectively. Conclusion: HAP/AZ31B had excellent biological safety and biocompatibility, which would be a new degradable and biomedical material.
刘魁,郭磊,黄晶晶,杨柯. AZ31B镁合金植入小鼠的生物相容性考察[J]. 中国生物工程杂志, 2008, 28(3): 59-63.
. Study on biocompatibility of AZ31B magnesium alloy in mice. China Biotechnology, 2008, 28(3): 59-63.
https://manu60.magtech.com.cn/biotech/CN/ 或 https://manu60.magtech.com.cn/biotech/CN/Y2008/V28/I3/59
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