As the long-time and unscientific use of biocide in power plant’s Cycling Cooling Water System, bacterial resistance to?biocides is becoming stronger and stronger. Research on the resistant mechanism has certain theoretical value and practical value. This paper reviews the recent research progress about the sulfate-reducing bacterial resistance and resistance mechanisms to various biocides. Main content: the concept of bacterial resistance to biocide, the status quo of bacterial drug-resistant, biocide’s bactericidal mechanisms and bacterial resistant mechanism.