Abstract: Based on the multimodel datasets of three representative concentration pathway (RCP) emission scenarios from IPCC5, the response of yield and accumulative evapotranspiration (ET) of winter wheat to climate change in the future were assessed by VIP model. The results showed that if effects of CO₂ enrichment were excluded, temperature rise would lead to a reduction in the length of the growing period for wheat under the three climate change scenarios, and the wheat yield and ET presented a decrease tendency. The positive effect of atmospheric CO₂ enrichment could offset most negative effect introduced by temperature rising, indicating that atmospheric CO₂ enrichment would be the prime reason of the wheat yield rising in future. In 2050s, wheat yield would increase 14.8% (decrease 2.5% without CO₂ fertilization), and ET would decrease 2.1% under RCP4.5. By adoption of new crop variety with enhanced requirement on accumulative temperature, the wheat yield would increase more significantly with CO₂ fertilization, but the water consumption would also increase. Therefore, cultivar breeding, new irrigation techniques and agronomical management should be explored under the challenges of climate change in the future.