| 邹文卫,翟正平,赵连东,陈 明,严从阳.荷丹片联合依达拉奉治疗急性脑梗死的临床效果及对血清IFN-γ，Ang-2，Hcy水平的影响[J].,2017,17(23):4502-4505 |
| 荷丹片联合依达拉奉治疗急性脑梗死的临床效果及对血清IFN-γ，Ang-2，Hcy水平的影响 |
| Clinical Effect of Hedanpian Combined with Edaravone in Treatment of Acute Cerebral Infarction and Influence on Serum Levels of IFN-γ, Ang-2 and Hcy |
| 投稿时间：2017-01-15 修订日期：2017-02-12 |
| DOI：10.13241/j.cnki.pmb.2017.23.023 |
| 中文关键词: 急性脑梗死 荷丹片 依达拉奉 临床效果 干扰素-γ 促血管生成素Ⅱ 同型半胱氨酸 |
| 英文关键词: Acute cerebral infarction HeDanPian Edaravone Clinical effect Interferon-γ Angiogenin Ⅱ Homocysteine |
| 基金项目:江苏省自然科学基金项目（08N06573） |
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| 中文摘要: |
| 摘要 目的：探讨荷丹片联合依达拉奉治疗急性脑梗死的临床效果及其对血清干扰素-γ(IFN-γ)、促血管生成素Ⅱ(Ang-2)、同型半胱氨酸(Hcy)水平的影响。方法：将102例急性脑梗死患者按抽签法分作对照组与实验组，每组各51例。对照组采用依达拉奉治疗，静脉滴注30mg依达拉奉，早晚各1次；实验组基于对照组加用荷丹片治疗，口服14.6 g荷丹片，早中晚各1次。比较两组疗效、治疗前后神经功能缺损评分(NIHSS)、血清IFN-γ、Ang-2、Hcy、丙二醇(MDA)、超氧化物歧化醇(SOD)、白细胞介素-6、10(IL-6、IL-10)、肿瘤坏死因子-α(TNF-α)水平及不良反应的发生情况。结果：实验组总有效率、血清Ang-2、SOD、IL-10水平均显著高于对照组，NIHSS、血清IFN-γ、Hcy、MDA、IL-6、TNF-α水平均明显低于对照组，差异均有统计学意义(P<0.05)。两组不良反应的发生率比较差异无统计学意义(P>0.05)。结论：荷丹片联合依达拉奉用于急性脑梗死的疗效肯定，可调节血清IFN-γ、Ang-2、Hcy的表达，对氧化应激及炎症反应均有改善作用。 |
| 英文摘要: |
| ABSTRACT Objective: To research the clinical effect of HeDanPian combined with edaravone in the treatment of acute cerebral in- farction and the influence on serum levels of interferon-γ(IFN-γ), promote angiogenin Ⅱ(Ang-2), homocysteine (Hcy). Methods: 102 cases of patients with acute cerebral infarction were selected and randomly divided into the control group and the experimental group, with 51 cases in each group. The control group was treated with edaravone, intravenous infusion of 30mg edaravone, 1 time in the morn- ing and night; The experimental group was treated based on the control group treated with HeDanPian, oral HeDanPian 14.6 g, 1 time in the early to middle. The curative effect, nerve function defect score (NIHSS), serum IFN-γ, Ang-2, Hcy, propylene glycol (MDA), su- peroxide disproportionation alcohol (SOD), interleukin 6, 10 (IL-6, IL-10), tumor necrosis factor-α(TNF-α) levels, incidence of adverse reactions were compared between two groups. Results: After treatment, the total effective rate, serum Ang-2, SOD, IL-10 levels of exper- imental group were higher than those of the control group(P<0.05), the NIHSS, serum IFN-γ, Hcy, MDA, IL-6, TNF-α levels of experi- mental group were lower than those of the control group(P<0.05). No significant difference was found in the incidence of adverse reac- tions was found between the two groups(P>0.05). Conclusion: HeDanPian combined with edaravone was effective in the treatment of acute cerebral infarction, which could regulate the expression of serum IFN-γ, Ang-2 and Hcy, improve the oxidative stress and inflam- mation. |
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