| 李维琴王兴胡晓燕陈丽霞常君.血清chemerin 水平与代谢综合征患者合并冠心病的相关性研究[J].,2012,12(18):3544-3546 |
| 血清chemerin 水平与代谢综合征患者合并冠心病的相关性研究 |
| The Association of Serum Chemerin Levels with the Presence of CoronaryArtery Disease in Patients with Metabolic Syndrome |
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| DOI： |
| 中文关键词: 代谢综合征 冠心病 脂肪因子 生物学标记物 |
| 英文关键词: Metabolic syndrome Coronary artery disease Adipokine Biomarker |
| 基金项目: |
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| 中文摘要: |
| 目的：旨在探讨血清脂肪因子chemerin 水平与代谢综合征患者合并冠心病的相关性。方法：共纳入116 名代谢综合征患者，
将所有患者分为两组，合并冠心病组(CAD+, n=47)及未合并冠心病组(CAD-, n=69)，使用酶联免疫吸附(ELISA)法测量每组血清的
血清chemerin 水平。结果：CAD+ 组患者的血清chemerin 水平较CAD- 组患者显著升高(129.83±29.18 vs 94.01±23.54 ng/mL;
P<0.01)，多元Logistic 回归分析结果显示血清chemerin 水平与代谢综合征患者合并冠心病存在独立相关性(优势比1.565, 95%
可信区间1.104-2.876; P<0.05)。结论：血清chemerin 水平是代谢综合征患者合并冠心病的独立危险因子，血清chemerin 可能是预
测代谢综合征患者发生冠心病风险的重要的生物学标记物。 |
| 英文摘要: |
| Objectives: The aim of this study is to investigate the correlation of serum chemerin levels with coronary artery disease
(CAD) in patients with metabolic syndrome (MetS). Methods: 116 patients with MetS were included in this study. All the patients were
classified as patients with CAD (CAD+, n=47) or as without CAD (CAD-, n=69). Serum chemerin levels were measured by enzymelinked
immunosorbent assay (ELISA). Results: Serum chemerin levels were significantly higher in MetS patients with CAD compared
with those without CAD (129.83±29.18 vs 94.01±23.54 ng/mL; P<0.01). Multivariate logistic regression revealed that serum chemerin
levels were independently associated with the presence of CAD in patients with MetS (odds ratio 1.565, 95% confidence interval
1.104-2.876; P<0.05). Conclusion: Serum chemerin levels were an independent determinant of the presence of CAD in MetS patients.
These results demonstrated that chemerin might be a potentially useful biomarker for predicting the presence of CAD in MetS patients. |
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